Part of the Blue Design Alliance, the Design for Social Impact postgraduate course is a practical course that considers and analyzes emerging global issues to find effective local responses with the support of a specialized faculty and inspiring international guests. In the current context of crisis and conflict, marked by growing social inequalities and exclusion and injustice, Design is called to greater involvement and solidarity, activism and awareness in its social intervention. By highlighting collaborative, participatory and co-design methodologies which are integrated into translocal, self-organized and decentralized processes, this postgraduate course is committed to a practice-led approach and to critical and systemic thinking. This results in sensitive and supportive ways of designing, capable of generating socially effective change.